P450 Cytochromes
Living organisms during the course of evolution, and during their lives, are subject to different environmental pressures, these factors can be environmental, biological or chemical. Under these pressures organisms must react, adapt or perish.
One of the constant and strongest pressures is the chemical onslaught of the most varied sources, that enter the body through food or air. Nutrients entering orally with others thato are not. Among them there are those that are not absorbed and excreted easily. But there are others of more recent origin, artificial synthesis, toxic natural synthesis or in the case of humans, drugs, called xenobiotics.
What does an organism do when exposed to chemicals that it may only find once in its life? It would be unreasonable and impractical for the body to generate biochemical mechanisms, enzymes, degradation and excretion pathways for each molecule. The more efficient system would involve a general mechanism which is responsible for ridding the body of the highest numbers of molecules simultaneously. The immune system has an action on a large number of cases, but there is another set of rich functionality and wide action, P450 Cytochrome Enzymes.
Most xenobiotics are fat soluble, lipid soluble compounds, so that these cross biological membranes easily and accumulate in fatty tissues and cells in other tissues and are in sufficient quantity (which depends on the type of chemical) interference with normal metabolic processes in the form of toxicological and pharmacological responses.
The method of action of P450 Cytochrome enzymes is to introduce a functional group to the lipophilic compound, or make it more soluble, and therefore more easily excreted.
The p450 cytochrome is very important to our health and I am happy you made this clear to all.
This information about the p450 cytochrome is very valuable for a researcher and anybody interested. The cytochrome has a profound effect on our wellbeing, psychological as well as physical.
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very interesting read about the p450 cytochrome. certainly helped me understand more now I can read on through your other posts.
Nowdays the most important thing is for our organism to be able to extract all the chemicals and bad stuff that are out there.So if we can find a way to help our body to do that then we are very lucky. Thank you for your work and studies.
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